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Cellular Differentiation

imatge Central Grup Recerca

Scientific Team

Researchers
Maribel Parra
Predoctoral researchers
Alba Azagra
Technicians
Olga Maria Collazo

Research lines

  • Study of the epigenetic mechanisms involved in the lineage commitment and differentiation of hematopoietic cells
  • Role of histone deacetylases in hematological diseases such as leukemia and lymphomas

1. Rodríguez-Ubreva J, Ciudad L, Gómez-Cabrero D, Parra M, Bussmann LH, di Tullio A, Kallin EM, Tegnér J, Graf T, Ballestar E. Pre-B cell to macrophage transdifferentiation without significant promoter DNA methylation changes. Nucleic Acids Res. 2012. 40(5):1954-1968.

 

2. Rafati H*, Parra M*, Hakre S, Moshkin Y, Verdin E, Mahmoudi T. Repressive LTR nucleosome positioning by the BAF complex is required for HIV latency. PLoS Biol. 2011. 9(11):e1001206. (*First co-authors)

 

3. Parra M* and Verdin E*. Regulatory signal transduction pathways for class IIa histone deacetylases. Current Opinion in Pharmacology. 2010. 10(4): 450-60 (*corresponding authors) (invited review)

 

4. Bussmann L*, Schubert A*, Vu Manh T*, De Andres L, Desbordes SC, Parra M, Zimmermann T, Rapino F, Rodriguez-Ubreva J, Ballestar E and Graf T. A robust and highly efficient immune cell reprogramming system. Cell Stem Cell. 2009. 5:554-66 (*First co-authors) (selected for the journal cover)

 

5.  Parra M. Epigenetic events during B lymphocyte development. Epigenetics. 2009. 4(7): 462-68 (invited review) 

 

6. Wang S, Li X, Parra M, Verdin E, Bassel-Duby R, Olson EN. Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7. Proc Natl Acad Sci U S A. 2008. 105(22):7738-43 

 

7. Parra M, Mahmoudi T and Verdin E. Myosin phosphatase dephosphorylapes HDAC7, controls its nucleo-cytoplasmic shuttling and inhibits apoptosis in thymocytes. Genes and Development. 2007. 21(6):638-43 

 

8. Mahmoudi T, Parra M, Vries R, Kauder S, Verrijzer P, Ott M and Verdin E. The SWI/SNF Chromatin-Remodeling Complex is a Cofactor for Tat Transactivation of the HIV Promoter. Journal of Biological Chemistry. 2006. 281(29): 19960-8 

 

9. Parra M,Kasler H, McKinsey TA, Olson EN and Verdin E. Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation. Journal of Biological Chemistry. 2005. 280(14): 13762-70

imatge personal
 

Group leader

Maribel Parra
Telephone  
+34 932607133
E-mail  
mparra@idibell.cat
 
© 2017 Institut d'Investigació Biomèdica de Bellvitge



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