logo IDIBELL
Català  |   Castellano  |   English
Search
The InstituteResearchWhat's onPlatformsJoin usTools
 

Chromatin and Disease


Introduction

Research in our laboratory focuses in epigenetic deregulation mechanisms in the immune system, particularly in the context of autoimmune disease and different differentiation models relevant to immune-related disease.



Research lines

. Epigenetic Deregulation in Autoimmune Disease.

 

. Epigenetic Mechanisms in Differentiation Processes relevant to Autoimmune Disease.

. Epigenetic Deregulation Processes involved in Haematopoietic Malignancies.


Selected papers

 

Rodríguez-Cortez, V.C., del Pino-Molina, L., Rodríguez-Ubreva, J., Ciudad, L., Gómez-Cabrero, D.,  Company, C.,  Urquiza, J.M., Tegnér, J., Rodríguez-Gallego, C., López-Granados, E., and Ballestar, E. (2015) Monozygotic Twins Discordant for Common Variable Immunodeficiency Reveal Impaired DNA Demethylation during Naïve-to-Memory B-Cell Transition. Nature  Communications 6, 7335.


De la Rica, L., García-Gómez, A., Comet, N.R.,  Rodríguez-Ubreva, J., Ciudad, L., Vento-Tormo, R., Company, C., Álvarez-Errico, D., García, M., Gómez-Vaquero, C., and Ballestar, E. (2015) NF-kB-direct activation of microRNAs with repressive effects on monocyte-specific genes is critical for osteoclast differentiation. Genome Biology 16, 2.

 

 

Álvarez-Errico, D., Vento-Tormo, R., Sieweke, M. and Ballestar, E. (2015) Epigenetic control in myeloid cell differentiation, identity and function. Nature Reviews Immunology 15, 7–17.

 

Rodriguez-Ubreva, J., Ciudad, L., van Oevelen, C., Parra, M., Graf, T., and Ballestar, E. (2014) C/EBPa-Mediated Activation of miR-34a and miR-223 Inhibits Lef1 Expression to Achieve Efficient Reprogramming into Macrophages. Molecular and Cellular Biology 34, 1145–1157.

 

De la Rica, L., Rodríguez-Ubreva, J., García, M., Islam, A.B.M.M.K., Urquiza, J.M., Hernando, H., Christensen, J., Helin, K., Gómez-Vaquero, C., and Ballestar, E. (2013) PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation. Genome Biology 14(9), R99.

 

Hernando, H., Islam, A., Rodríguez-Ubreva, J., Forné, I., Ciudad, L., Imhof, A., Shannon-Lowe, C., and Ballestar, E.  (2013) Epstein Barr Virus-mediated transformation of B cells induces global chromatin changes independent to the acquisition of proliferation. Nucleic Acids Research 42, 249–263.

 

Hernando, H., Shannon-Lowe, C., Islam, A.B.M.M.K., Al-Shahrour, F., Rodríguez-Ubreva, J., Rodríguez-Cortez, V.C., Javierre, B.M., Mangas, C., Fernandez, A.F., Parra, M., Delecluse, H-J., Esteller, M., Lopez-Granados, E., Fraga, M.F., Lopez-Bigas, N., and Ballestar, E. (2013) The B cell transcription program mediates hypomethylation and overexpression of key genes in Epstein-Barr virus-associated proliferative conversion. Genome Biology 14(1),R3.

 

De la Rica, L., Urquiza, J.M., Gómez-Cabrero, D., Islam, A.B.M.M.K., López-Bigas, N., Tegnér, J., Toes, R.E.M., and Ballestar, E. (2013) Identification of Novel Markers in Rheumatoid Arthritis through Integrated Analysis of DNA methylation and microRNA Expression. Journal of Autoimmunity 41, 6-16.

 

Kallin, E.M., Rodríguez-Ubreva, J., Christensen, J., Cimmino, L., Aifantis, I., Helin, K., Ballestar, E., Graf, T. (2012) Tet2 Facilitates the Derepression of Myeloid Target Genes during CEBPα-Induced Transdifferentiation of Pre-B Cells. Molecular Cell 48, 266–276. 

 

Ballestar E. (2011) Epigenetics Alterations in Autoimmune Rheumatic Diseases. Nature Reviews Rheumatology 7, 263-271. 

 

Rodriguez-Ubreva, J., Ciudad, L., Gómez-Cabrero, D., Parra, M., Bussmann, L.H., di Tullio, A., Kallin, E.M., Tegnér, J., Graf, T. and Ballestar, E. (2011) Pre-B Cell to Macrophage Transdifferentiation Without Significant Promoter DNA Methylation Changes. Nucleic Acids Research 40, 1954-1968.

 

Rodriguez-Cortez, V.C., Hernando, H., de la Rica, L., Vento, R., and Ballestar, E. (2011) Epigenomic Deregulation in the Immune System. Epigenomics 3, 697-713.

 

Javierre, B.M., Fernandez, A.F., Richter, J., Al-Shahrour, F., Martin-Subero, J.I., Rodriguez-Ubreva, J., Berdasco, M., Fraga, M.F., O'Hanlon, T.P., Rider, L.G., Jacinto, F.V., Lopez-Longo, F.J., Dopazo, J., Forn, M., Peinado, M.A., Carreño, L., Sawalha, A.H., Harley, J.B., Siebert, R., Esteller, M., Miller, F.W., and Ballestar, E. (2010) Changes in the Pattern of DNA Methylation Associate with Twin Discordance in Systemic Lupus Erythematosus. Genome Research. 20, 170-179.


Bussman, L., Schubert, A., Vu Manh, T.P., DE Andres, L., Desbordes, S., Parra, M., Zimmermann, T., Rapino, F., Rodriguez-Ubreva, J., Ballestar, E., Graf, T. (2009) A robust and highly efficient immune cell reprogramming system. Cell Stem Cell 5, 554-566.

imatge personal
 

Group leader

Esteban Ballestar
Telephone  
+34 932607133
E-mail  
eballestar@idibell.cat
 
© 2017 Institut d'Investigació Biomèdica de Bellvitge



Results by pageInitial date
Select date
TitleFinal date
Select date
Search


Your password is about to expire. Please, write in a new password to continue

Remember this password allows you to access to all IDIBELL’s web applications

New password:
Confirm new password:

Accept



Your password is about to expire. Please, write in a new password to continue

Remember this password allows you to access to all IDIBELL’s web applications

New password:
Confirm new password:

Accept


Cancell

Passwords doesn’t match
The password must have at least 6 characters
The new password can not contain special characters
User register

Name
Surname
Second Surname
E-mail
User
Password
Language


Accept


Cancell




Encara no heu contestat l'enquesta de satisfacció sobre la píndola formativa sobre patents. No trigareu més de cinc minuts a fer-ho. La vostra opinió és molt important per millorar l’IDIBELL.

Voleu fer l’enquesta ara?

Yes

No




Further personal and contact information is needed to maintain IDIBELL databases.

Do you wish to fill the form now?

Yes

No





Please, remember to introduce your holiday’s planning in the application

Accept

Cancell