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Colorectal Cancer

Introduction

The Colorectal Cancer research group a highly multidisciplinary team composed of professionals from different areas such as medicine, surgery, biology, biostatistics, bioinformatics, etc.

 

Together, they join efforts working on discovery and validation molecular biomarkers in colorectal cancer, both in diagnosis and prognosis, as therapeutic response and potential treatments toxicity. Furthermore, also focus their research on identifying new therapeutic targets, thanks to areas as the genetic epidemiology and molecular biology of cancer.



Research lines

Molecular characterization of digestive tumors by genomic, transcriptomic and proteomic analyses level.

 

 Construction of molecular signatures for prognostic prediction in colorectal cancer.


 Search, evaluation and validation of new diagnosis biomarkers in colorectal cancer.

 

 Genetic determinants of chemotherapy toxicity in colorectal cancer.


Selected papers (2013)

 

Fernandez-Rozadilla, C.; Cazier, J. B.; Moreno, V.; Crous-Bou, M.; Guino, E.; Duran, G.; Lamas, M. J.; Lopez, R.; Candamio, S.; Gallardo, E.; Pare, L.; Baiget, M.; Paez, D.; Lopez-Fernandez, L. A.; Cortejoso, L.; Garcia, M. I.; Bujanda, L.; Gonzalez, D.; Gonzalo, V.; Rodrigo, L.Pharmacogenomics in colorectal cancer: a genome-wide association study to predict toxicity after 5-fluorouracil or FOLFOX administration.

Pharmacogenomics Journal.  2013 Jun;13(3):209-17.

 

Crous-Bou M., Rennert G., Cuadras D.,  Salazar R., Cordero D., Rennert H.S., Lejbkowicz F.,  Kopelovich L., Lipkin S.M.,  Gruber S.B., Moreno V.

Polymorphisms in Alcohol Metabolism Genes ADH1B and ALDH2, Alcohol Consumption and Colorectal Cancer                              

PLoS oNE. November 25, 2013

 

Carmona, F.J., Azuara D.,  Berenguer-Llergo A.,  Fernandez, A.F., Biondo S., de Oca J.,  Rodriguez-Moranta F., Salazar R., Villanueva A.,  Fraga M.F., Guardiola J., Capella G.,  Esteller M., Moreno V.

DNA Methylation Biomarkers for Noninvasive Diagnosis of Colorectal Cancer   .

Cancer prevention Research. 2013 Jul;6(7):656-65.

 

Azuara D, Rodriguez-Moranta F, de Oca J, Sanjuan X, Guardiola J, Lobaton T, Wang A, Boadas J, Piqueras M, Monfort D, Galter S, Esteller M, Moreno V, Capellá G.

Novel methylation panel for the early detection of neoplasia in high-risk ulcerative colitis and Crohn's colitis patients.

Inflammatory bowel diseases. 2013 Jan;19(1):165-73.

 

Roepman P, Schlicker A, Tabernero J, Majewski I, Tian S, Moreno V, Snel MH, Chresta CM, Rosenberg R, Nitsche U, Macarulla T, Capella G, Salazar R, Orphanides G, Wessels LF, Bernards R, Simon IM.

Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition

International journal of cancer.2014 Feb 1;134(3):552-62

 

Tabernero J., Garcia-Carbonero R.,  Cassidy J., Sobrero A.,  Van Cutsem E.,  Koehne C.H., Tejpar S., Gladkov O., Davidenko I., Salazar R., Vladimirova L., Cheporov S.,  Burdaeva O.,  Rivera F.,  Samuel L., Bulavina I.,  Potter V.,  Chang Y.,  Lokker N.A., O'Dwyer  P. J.

Sorafenib in Combination with Oxaliplatin, Leucovorin, and Fluorouracil (Modified FOLFOX6) as First-line Treatment of Metastatic Colorectal Cancer: The RESPECT  Trial.

Clinical Cancer Research. 2013 May 1;19(9):2541-50. 

imatge personal
 

Group leader

Victor Moreno
Telephone  
+34 932607434
E-mail  
vmoreno@idibell.cat
 
© 2017 Institut d'Investigació Biomèdica de Bellvitge



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