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Neuropharmacology and pain

Introduction

The Neuropharmacology and Pain research group embrace all members of the Pharmacology Unit located at the Department of Pathology and Experimental Therapeutics, Faculty of Medicine, Campus Bellvitge, Universitat de Barcelona. Our main goal focuses on joining together the two main aspects of G protein-coupled receptors (GPCRs) pharmacology, namely basic and clinical GPCR pharmacology. Thus, we are composed by experimental pharmacologists that work in the research facilities installations of the UB and by the clinical pharmacologists working in the Clinical Pharmacology Service at the University Hospital of Bellvitge (HUB).




Research lines

. Oligomerization of receptors, ion channels and interacting proteins in the context of neuropsychiatric diseases and pain.


. Study of the functionality of oligomeric interactions in animal models to establish the basis of combined drug treatment.

 

. Clinical evaluation of drugs in neuropsychiatric diseases and pain by pharmacoepidemiological methods


Selected papers (2014)

  

Fernández-Dueñas, V., Taura, J.J., Cottet, M., Gómez-Soler, M., López-Cano, M., Ledent, C., Watanabe, M., Trinquet, E., Pin, J.P., Luján, R., Durroux, T. & Ciruela, F. (2015). Untangling dopamine-adenosine receptor assembly in experimental parkinsonism. 

Disease Models & Mechanisms 8 (1), 57-63.

 

Fernández-Dueñas, V., Gómez-Soler, M., López-Cano, M., Taura, J.J., Ledent, C., Watanabe, M., Jacobson, K.A., Vilardaga, J.P. & Ciruela, F. (2014). Uncovering caffeine adenosine A2A receptor inverse agonism in experimental parkinsonism. ACS Chemical Biology 9 (11), 2496-2501.

 

García-Negredo, G., Soto, D., Llorente, J., Morató, X., Galenkamp, K.M.O., Gómez-Soler, M., Fernández-Dueñas, V., Adelman, J.P., Shigemoto, R., Fukozawa, Y., Luján, R. & Ciruela, F. (2014). 

Co-assembly and coupling of mGlu5 receptors and SK2 channels. Journal of Neuroscience 34 (44), 14793?14802.

 

Pedrós, C., Quintana, B., Rebolledo, M., Porta, N., Vallano, A., & Arnau, J.M. (2014). Prevalence, risk factors and main features of 

adverse drug reactions leading to hospital admission. European  

Journal of Clinical Pharmacology 70(3), 361-367.

 

Bahamonde, M.I.*, Taura, J.*, Paoletta, S.*, Gakh, A.A., Chakraborty, S., Hernando, J., Fernández-Dueñas, V., Jacobson, K.A., Gorostiza, P. 

& Ciruela, F. (2014). Photomodulation of G protein-coupled adenosine receptors by a novel light-switchable ligand. Bioconjugate Chemistry

25 (10), 1847-1854.

Ministerio de Economía y Competitividad, Instituto de Salud Carlos III-Spanish Government, Grant PIE14/00034 as a Principal Investigator Partner in the Consortium headed by Isidre Ferrer Abizanda Project title: Epigenetic and environmental factors bracing cognitive impairment and late-onset depression in elderly and early stages of Alzheimer disease.?

Duration: 2015-2017.

 

Agentschap voor Innovatie door Wetenschap en Technologie (IWT, Flemish Agency for Innovation by Science and Technology), Grant

SBO-140028 as a Principal Investigator Partner in the Consortium headed by Kathleen Van Craenenbroeck.

Project title: ?Unravelling the pharmaceutical potential of receptor heterodimers for therapeutic interventions in CNS disorders.?

Duration: 2015-2017.

 

El proyecto con expediente: PT13/0002/0002 y título “Plataforma de unidades de investigación clínica y ensayos clínicos“. Convocatoria Plataformas de apoyo a la investigación en ciencias y tecnologías de la salud, con un presupuesto de 774.800,00 € cofinanciado por el Fondo de Desarrollo Regional (FEDER) de la Unión Europea y el Instituto de Salud Carlos III. El Dr. Antonio Vallano Ferraz como IP.

 

 

ERA-Net NEURON 2012, Ministerio de Economía y Competitividad-Spanish Government, Grant PCIN-2013-019-C03-03 as a Principal Investigator.

Project title: ?Deciphering the role of peripheral and central nervous system metabotropic glutamate receptors in neurophatic pain with photoactivable ligands.?

Duration: 2013-2015.

imatge personal
 

Group leader

Francisco Ciruela
Telephone  
+34 934024280
E-mail  
fciruela@idibell.cat
 
© 2017 Institut d'Investigació Biomèdica de Bellvitge



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