logo IDIBELL
Català  |   Castellano  |   English
Search
The InstituteResearchWhat's onPlatformsJoin usTools
 

Physiology and pathology of the functional relationship between glia and neurons

imatge Central Grup Recerca

Scientific Team

Researchers
Raul Estevez Alejandro Barrallo
Postdoctoral researchers
Sonia Sirisi
Predoctoral researchers
Xabier Elorza , Héctor Gaitan, Carla Pérez

Research lines

Role of glial chloride channels in brain homeostasis. (Barrallo/Estévez)

 

Rare genetic disorders caused by dysfunction of chloride channels (Barrallo/Estévez)

 

Involvement of BDNF downstream genes in the CNS development in animal models and in

human neurodevelopmental pathologies as autism spectrum disorders, early epileptic

encephalopathy and perinatal acquired brain injury (hypoxia-ischemia, IUGR…).  Alcántara

 

Modulation of the neurovascular niche by metabolic and biomaterials approaches to promote

endogenous CNS regeneration after a lesion in the developing CNS.  Alcántara


Alvarez Z, Hyroššová P, Perales JC, Alcántara S. (2014) Neuronal Progenitor Maintenance Requires Lactate Metabolism and PEPCK-M-Directed Cataplerosis. Cerebral Cortex, Dec 1. pii: bhu281. 1-13

 

Barrallo-Gimeno A, Gradogna A, Zanardi I, Pusch M, Estévez R.

Regulatory/Auxiliary subunits of CLC chloride channel/transport proteins.

J Physiol. (2015) Mar 11. doi: 10.1113/JP270057

 

. Sirisi S, Folgueira M, López-Hernández T, Minieri L, Pérez-Rius C, Gaitán-Peñas H, Zang J, Martínez A, Capdevila-Nortes X, De La Villa P, Roy U, Alia A, Neuhauss S, Ferroni S, Nunes V, Estévez R*, Barrallo-Gimeno A* (*shared last authorship)

Megalencephalic leukoencephalopathy with subcortical cysts protein 1 regulates glial surface localization of GLIALCAM from fish to humans.

Hum Mol Genet. 2014 Oct 1;23(19):5069-86. doi: 10.1093/hmg/ddu231

 

Arnedo T, López-Hernández T, Jeworutzki E, Capdevila-Nortes X, Sirisi S, Pusch M, Estévez R.

Functional analyses of mutations in HEPACAM causing megalencephalic leukoencephalopathy.

Hum Mutat. 2014 Oct;35(10):1175-8. doi: 10.1002/humu.22622. 

 

Hoegg-Beiler MB, Sirisi S, Orozco IJ, Ferrer I, Hohensee S, Auberson M, Gödde

K, Vilches C, de Heredia ML, Nunes V*, Estévez R*, Jentsch TJ*. (*shared last authorship)

Disrupting MLC1 and GlialCAM and ClC-2 interactions in leukodystrophy entails glial chloride channel dysfunction.

Nat Commun. 2014 Mar 19;5:3475. doi: 10.1038/ncomms4475

Agency: Ministerio de Ciencia e Innovación: MAT2011-29778-C02-02

Title: Modulación del Nicho Neurovascular Durante el Desarrollo y la Regeneración Mediada por Biomateriales.

IP: Soledad Alcántara

N Participants: 3

Period: (1-1- 2012- 30-6-2015)

Amount: 109.999,89 €.  

 

Agency: Ministerio de Educación y Ciencia: MAT2008-06887-C03-02/MAT

Title: Funcionalización de Biomateriales para la promoción de la migración neuronal y regeneración

IP: Soledad Alcántara

N Participants: 3

Period 1-1-2009 a 31-12-2011

Amount: 108.000,00 €.

 

Fisiologia i patologia de la relació funcional glia-neurona. Grup de recerca emergent de la Generalitat. From 2009 to 2013. IP & Coordinator: Raúl Estévez

 

Megalencephalic leukoencephalopathy with subcortical cysts: from molecular basis to search for therapy. E-RARE. From: 2010-2012. IP & Coordinator: Raúl Estévez

 

Animal models of megalencephalic leukoencephalopathy. ELA Research Foundation. From: 2010-2012. IP & Coordinator: Raúl Estévez

 

Icrea Academia Prize to Raúl Estévez. 2010-2014

imatge personal
 

Group leader

Raul Estevez
Telephone  
+34 934039782
E-mail  
restevez@idibell.cat
 
© 2017 Institut d'Investigació Biomèdica de Bellvitge



Results by pageInitial date
Select date
TitleFinal date
Select date
Search


Your password is about to expire. Please, write in a new password to continue

Remember this password allows you to access to all IDIBELL’s web applications

New password:
Confirm new password:

Accept



Your password is about to expire. Please, write in a new password to continue

Remember this password allows you to access to all IDIBELL’s web applications

New password:
Confirm new password:

Accept


Cancell

Passwords doesn’t match
The password must have at least 6 characters
The new password can not contain special characters
User register

Name
Surname
Second Surname
E-mail
User
Password
Language


Accept


Cancell




Encara no heu contestat l'enquesta de satisfacció sobre la píndola formativa sobre patents. No trigareu més de cinc minuts a fer-ho. La vostra opinió és molt important per millorar l’IDIBELL.

Voleu fer l’enquesta ara?

Yes

No




Further personal and contact information is needed to maintain IDIBELL databases.

Do you wish to fill the form now?

Yes

No





Please, remember to introduce your holiday’s planning in the application

Accept

Cancell