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Resistance to Anti-angiogenic Therapies and Tumour Malignization

imatge Central Grup Recerca

Scientific Team

Researchers
Oriol Casanovas
Collaborators
Lidia Moserle
Predoctoral researchers
Laura Martin

Introduction

The main subject of this research subgroup is the tumour adaptation to the anti-angiogenic therapies, particularly focusing on the VEGF/R path, both in cancer in animal models and in cancer patients. The particular interest of the research group is focusing on two aspects: 1) the mechanisms of tumour revascularization that lead to resistance to these therapies, and 2) the tumour adaptation to these therapies that lead to increase the invasion and the production of more metastasis (malignant tumour). The applicability of these results is been focused on renal tumors and neuroendocrine tumours, since they are tumour typically treated with antiangiogenic that can benefit from the preclinical results.


Research group

Tumour Angiogenesis

Research lines

. Mechanisms of resistance to antiangiogenic therapies in animal models and human tumours.

 

. Adaptation and malignancy mechanisms in response to antiangiogenic therapies in animal models and human tumours

 

. Contribution of stromal components in therapeutic resistance and tumour malignancy


Publications from our group (last 3 years):

 

Teulé A & Casanovas O* Targeted Oncology, 2012

 

Moserle L & Casanovas O* EMBO Molecular Medicine, 2012

 

Casanovas O* Journal of Clinical Investigation, 2011

 

Pàez-Ribes M , Allen E, Hudock J, Takeda T, Okuyama H, Viñals F, Inoue M, Bergers G, Hanahan D* & Casanovas O*. Cancer Cell, 2009

 

 

Collaborative publications (last 3 years):

 

Benedito R, Woeste M, Zamykal M, Radtke F, Duarte A, Rocha S, Casanovas O, Pytowski B & Adams R. Nature 2012.

 

Maione F, Capano S, Regano D, Zentilin L, Giacca M, Casanovas O, Bussolino F, Serini G and Giraudo E. Journal of Clinical Investigation 2012.

 

Franco M, Pàez-Ribes M, Cortez E, Casanovas O, Pietras K. Hormone and Metabolic Research, 2011.

 

Martinez-Poveda B, Gomez V, Alcaide-German M, Perruca S, Vazquez S, Alba LE, Casanovas O, Garcia-Bermejo ML, Peso L, Jimenez B. International Journal of Oncology, 2011.

 

Nardo G, Favaro E, Curtarello M, Moserle L, Zulato E, Persano L, Rossi E, Esposito G, Crescenzi M, Casanovas O, Sattler U, Mueller-Klieser W, Biesalski B, Thews O, Canese R, Iorio E, Zanovello P, Amadori A, Indraccolo S. Cancer Research, 2011.

 

Melo S, Villanueva A, Moutinho C, Davalos V, Spizzo R, Ivan C, Rossi S, Setien F, Casanovas O, Simo-Riudalbas L, Carmona J, Carrere J, Vidal A, Aytes A, Puertas S, Ropero S, Kalluri R, Croce CM, Calin GA, Esteller M. Proc Natl Acad Sci U S A, 2011.

 

Balart J, Pueyo G, de Llobet LI, Baro M, Sole X, Marin S, Casanovas O, Mesia R, Capella G. Radiation Oncology, 2011.

 

Del Valle-Pérez B, Martínez VG, Lacasa-Salavert C, Figueras A, Shapiro SS, Takafuta T, Casanovas O, Capellà G, Ventura F, Viñals F. The Journal of Biological Chemistry, 2010.

 

Castillo-Avila W, Piulats JM, Garcia Del Muro X, Vidal A, Condom E, Casanovas O, Mora J, Germà JR, Capellà G, Villanueva A, Viñals F. Clinical Cancer Research, 2009.

Title of the project or contract: “Stromal Contribution to Tumor Malignization after Anti-Angiogenic Therapies – STROMALIGN“
Funding agency and project reference: FP7 - ERC Starting Grants 2011 Ref. FP7-281830
Project period: 2012 - 2017
Budget: 1.495.796 Eur
Principal investigator: Oriol Casanovas

 

Title of the project or contract: "Malignización Tumoral en el Tratamiento Antiangiogénico: Mecanismos y Nuevas Dianas"
Funding agency and project reference: Plan Nacional de I+D+I, Proyectos de Investigación No Orientada. Ref. SAF2009-08375
Project period: 1/1/2010 - 31/12/2012
Budget: 254.100 Eur
Principal investigator: Oriol Casanovas

 

Title of the project or contract: "Hipoxia, Fenotipo Glicolítico y Angiogenesis Tumoral"
Funding agency and project reference: Grupo de la Red Temática de Investigación Cooperativa en Cáncer (RTICC) Ref. RD06/0020/0092
Project period: 2006-2009
Budget: 40.000 Eur/año
Principal investigator: Francesc Ventura (Coordinator)

 

Title of the project or contract: "Estudio Molecular y Funcional de la Invasión Tumoral en el Tratamiento Anti-Angiogénico Contra el Cáncer"Ministerio de Educación y Ciéncia Ref. SAF2006-00590
Project period: 2006-2009
Budget: 40.000 Eur/año
Principal investigator: Oriol Casanovas

imatge personal
 

Subgroup head (PI)

Oriol Casanovas
Telephone  
+34 932607344
E-mail  
ocasanovas@idibell.cat
 
© 2017 Institut d'Investigació Biomèdica de Bellvitge



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